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Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of gout (average 6% in early studies). Allopurinol-induced hypersensitivity reactions tend to occur more often in the presence of renal insufficiency and/or concomitant thiazide diuretic therapy. Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine to approximately 1/3 to 1/4 the usual dose. There are no data with amoxicillin and clavulanate potassium tablets and allopurinol administered concurrently. GastrointestinalA first of a kind case report, elevations in pancreatic exocrine enzyme level, new-onset type 1 diabetes mellitus, and allopurinol hypersensitivity syndrome have been reported in a 58-year-old Cambodian female. A 43-year-old female with chronic kidney disease developed fever, generalized morbilliform rash, leukocytosis with marked eosinophilia, and hepatic dysfunction 3 weeks after starting allopurinol therapy (300 mg/day for 3 days followed by 200 mg/day) for hyperuricemia and arthritis. At least 3 cases of allopurinol hypersensitivity syndrome have also been reported. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. Conversion to inactive 6-thiouric acid by xanthine oxidase is an important degradative pathway, and the inhibition of this pathway in patients receiving allopurinol is the basis for the azathioprine dosage reduction required in these patients (see Drug Interactions under PRECAUTIONS). Eleven days later (approximately 7 weeks after allopurinol was discontinued), both the hemoglobin level and reticulocyte count began to rise. )generic name: allopurinol class: antigout agents, antihyperuricemic agents1 review(s)Rate It!9.
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